PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age

Cognitive processes that require spatial information rely on synaptic plasticity in the dorsal CA1 area (dCA1) of hippocampus. Since function hippocampus is impaired aged individuals, it remains unknown how animals make choices. Here, we used IntelliCage to study behavioral support choices female mice living a group. As proxy training-induced plasticity, analyzed morphology dendritic spines and expression scaffold protein, PSD-95. We observed choice training young adult induced correlated shrinkage downregulation PSD-95 dCA1. Moreover, long-term depletion by shRNA dCA1 limited correct reward corner, while preference was intact. In contrast, old strategies characterized an increased tendency for perseverative visits social interactions. This strategy resulted robust corner during task. decreased correlation between size spines. Furthermore, did not impair place or mice. Thus, our data indicate PSD-95-dependent choices, observe cage mates stick preferred seek reward. resistant area. Overall, demonstrates combine alternative molecular approach consume rewards complex environment. SIGNIFICANCE STATEMENT It poorly understood aging affects cognitive functions. is, however, essential understand these develop therapeutic interventions successful aging. Our (i.e., information), Second, contribution functions changes with age.